Umgubo we-L-Tyrosine
i-l-tyrosine
intshayelelo emfutshane
I-Tyrosine (efinyeziweyo njengeTyr okanye i-Y) okanye i-4-hydroxyphenylalanine yenye yee-amino acids ezingama-22 ezisetyenziswa ziiseli ukwenza iiproteni. Ingasetyenziselwa ukwenza iiproteni kwiiseli, kunye nee-codons UAC kunye ne-UAU. Yi-amino acid engabalulekanga equlethe amaqela asecaleni e-polar kwaye inokwenziwa ngumzimba womntu. Igama elithi 'tyrosine' livela kwi-tyros yesiGrike, elithetha itshizi. Ekuqaleni kwenkulungwane ye-19, yafunyanwa okokuqala yingcali yemichiza yaseJamani u-Eustus von Libich kwitshizi ye-casein, kwaye xa isetyenziswa njengeqela elisebenzayo okanye elisecaleni, ibizwa ngokuba yi-tyrosine.
umsebenzi
Ukongeza ekubeni yi-protein amino acid, i-tyrosine idlala indima ekhethekileyo ekudluliseleni isignali kwiiproteni ngokuxhomekeka kumaqela asebenzayo e-phenolic. Umsebenzi wayo njenge-receptor yamaqela e-phosphate adluliselwa yi-protein kinases (ebizwa ngokuba yi-tyrosine kinase receptors), ngelixa i-phosphorylation yamaqela e-hydroxyl itshintsha umsebenzi weproteni ekujoliswe kuyo.
I-Tyrosine ikwadlala indima ebalulekileyo kwi-photosynthesis, isebenza njengomboneleli we-electron kwi-reduction reaction ye-oxidized chlorophyll kwi-chloroplasts (Photosystem II), i-deprotonation yamaqela e-phenolic OH, kwaye ekugqibeleni incitshiswe ngamaqoqo amane e-manganese angundoqo kwi-Photosystem II.
Imithombo yokutya
I-Tyrosine inokuveliswa kwi-phenylalanine emzimbeni kwaye inokufumaneka kukutya okuninzi okuneproteni ephezulu njengenkukhu, iturkey, intlanzi, ubisi, iyogathi, itshizi, itshizi, amandongomane, iialmond, imbewu yethanga, isesame, iisoya, iimbotyi zelima, iiavokhado kunye neebhanana.
I-L-tyrosine yi-amino acid engabalulekanga kwaye yenye yezona zinto zibalulekileyo kwindlela ye-methionine metabolism. Ifumaneka kakhulu kwizinto eziphilayo kwaye idlala indima ebalulekileyo kwiinkqubo ezininzi zebhayoloji.
I-L-tyrosine yinxalenye yeeproteni kwaye ithatha inxaxheba kwinkqubo yokwenziwa kweeproteni. Ikwangunobangela wezinto ezahlukeneyo ezisebenzayo kwi-bioactive, kubandakanya ii-neurotransmitters ze-catecholamine ezifana ne-dopamine, i-norepinephrine, kunye ne-adrenaline, kunye neehomoni ze-thyroid kunye ne-melanin.
Ukongeza, i-L-tyrosine ikwabandakanyeka ekuhlanganisweni kweemolekyuli ezibalulekileyo zebhayoloji ngothotho lwee-enzymes emzimbeni, ezifana ne-tyrosine kinase kunye ne-tyrosine hydroxylase, ezibandakanyekayo kwiindlela zokuhambisa imiqondiso ye-kinase kunye nolawulo lwe-physiological.
Ukutya kwe-L-tyrosine kunokufumaneka ngokutya, kunye nemithombo yokutya emininzi equka amandongomane, imbewu, inyama, intlanzi, kunye neemveliso zobisi. Ukongeza, i-L-tyrosine inokuguqulwa isuka kwenye i-amino acid, i-phenylalanine, ngendlela yokwenziwa kwe-tyrosine emzimbeni.
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